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Point-of-care testing (POCT) is used in emergency medicine as a quick and qualitative test for a treatment basis. Due to their rapid use, point-of-care tests have an advantage because a diagnosis can be made directly without the aid of a laboratory, or it can work as an easy means to confirm an existing diagnosis. The DIANEONATAL® POCT is a strip test based on GPBB as a bio marker for pre-eclampsia. Arranged in small rows on the multi-layer strip are monoclonal antibodies that catch GPBB (catch antibody).

After a drop of blood is added to the test, a second antibody (detect antibody), contained in a special buffer fluent, attaches itself to the other side of the GPBB molecule, positioned opposite of the catch antibody.
The detect antibody is coupled to gold particle causes a change in color. Once the blood sample on the absorbent strip passes along the antibody row, GPBB is bound and, with the help of the gold, the reaction is made visible.

Only 50 µl blood is needed to produce a solid test result. The test gives a result after 10-15 minutes. Pregnancy imposes metabolic stress, and pre-eclampsia is associated with cardiac complications. Although not as well-known as other common diseases, pre-eclampsia is a very common pregnancy complication (it occurs in about 6-8% of all pregnancies worldwide). If not treated properly, it can develop into an eclampsia which can be fatal. Therefore, it is very important to diagnose a pre-eclampsia as early and reliable as possible, to protect the mother's and her unborn child's life. Initial studies have shown that GPBB levels in the blood of pregnant women are significantly elevated.

The goal is to establish DIAGENICS DIANEONATAL® as a standard for the diagnosis and monitoring of pre-eclampsia. Presently, a big multinational study is being carried out to verify GPBB as a marker for pre-eclampsia. The DIANEONATAL® POCT is simple, fast, safe and reliable. World-wide marketing for the product is already being initiated.